Spinal Tolerance and Dependence: Some Observations on the Role of Spinal N-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

The continuous delivery of opiates can lead to a reduction in analgesic effects.In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component.Such loss of effect, Herbie Hose Clamps deemed to be tolerance in the present article, can be readily demonstrated in animals with repeat

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Assessment of Most Definite Reference Point on Tragus to Mark the Ala Tragus Line for Orientation of Occlusal Plane: A Systematic Review and Meta Analysis

Objective: This systematic review and meta-analysis aimed to establish the most appropriate posterior reference point on the tragus of the ear for orienting the occlusal plane in complete denture prosthesis, addressing the existing confusion regarding this crucial anatomical landmark.Methods: A comprehensive literature search identified 20 relevant

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Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

Here, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis (IA).We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium.The meta-a

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